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Some patients report a brief second wave of mild headaches when their dose increases, but this recurrence is typically shorter and less intense than the initial episode

However, improvements in multiple secondary endpoints involving measurements of fibrosis and liver function were observed in patients treated with both Firsocostat and Cilofexor, when compared with the placebo group

Doi:10.1056/NEJMoa2032183 Stierman B, Afful J, Carroll MD, et al

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Environmental cues included the illumination of the active nose-poke light to signal drug availability, while both the house light and cue light were extinguished during the time-out period